Sustainable human resource management (HRM), digitalization, and strategic alignment have become increasingly critical aspects for organizational resilience and competitiveness. The core demands of today’s environment in managing organizations and Human Resources, such as implementing emerging technology, particularly artificial intelligence, sustainability and green practices, thus managing a productive work environment, diversity and inclusion, hybrid teams and data security, require an effective response and an adequate strategy. These are the very complex processes that are accompanied by many challenges. This article analyses and explores the implementation and interconnections of sustainability and digital technologies in organizational HR practices through the literature review, emphasizing its importance as a critical aspect in achieving efficient operations and business success, 509 Third International Scientific Conference which have to be supported by an adequate strategy and key challenges for its integration into HR operations and alignment with organizational strategy.